Page 59 - ECBIP 2021_Program
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 MODERATED e-POSTER SESSION 04:
Central airways obstruction and foreign body extraction
PP27
Primer mediastinal leiomyoma is very rare. In this article, we aimed to present a case with a mass compressing the trachea in the lower mediastinum and diagnosed with Endobronchial Ultrasonography guided transbronchial needle aspiration (EBUS-TBNA). A 42-year-old male patient was admitted to our Chest Diseases Clinic. In the computed tomography of the thorax; 31x45x34 mm mass lesion was observed in the subcarinal area. Histologically, the tumor was diagnosed as Spindle cell mesenchymal neoplasia, smooth muscle-derived mesenchymal tumor (leiomyoma). The tumor was dissected and enucleated by thoracic surgeons. The patient, who did not require additional treatment and whose clinical and radiological findings improved, was discharged without complications.
        GIANT MEDIASTINAL LEIOMYOMA DIAGNOSED WITH EBUS-TBNA: CASE REPORT
Serap Duru1, Kubilay Inan2, Tugba Taskın Türkmenoglu3, Bahar Kurt1
1 University of Health Science Dıskapı Yıldırım Beyazıt Health Pratctice and Research Centers, Chest Disease, Ankara,Turkey,2 University of Health Science DıskapıYıldırım Beyazıt Health Pratctice and Research Centers,Thoax Surgery,Ankara,Turkey,3 University of Health Science DıskapıYıldırım Beyazıt Health Pratctice and Research Centers, Pathology, Ankara, Turkey
         Figure 1
Figure 2
          AN UNUSUAL CASE OF JUVENILE-ONSET RECURRENT RESPIRATORY PAPILLOMATOSIS WITH LOWER AIRWAY INVOLVEMENT IN A 15-MONTH-OLD BOY
Konstantinos Douros1, Dafni Moriki1, Olympia Sardeli1, Angeliki Galani1, Ioannis G. Panayiotides2, Periklis Foukas2, Vassiliki Papaevangelou1, Diagoras Zarganis3, Savvas Kaklis4, Chrysanthos Alexopoulos5, Kostas N. Priftis6
1 3rd Department of Paediatrics, University General Hospital Attikon, Athens, Greece 2 2nd Department of Pathology, University General Hospital Attikon, Athens, Greece 3 2nd Department of Paediatrics, Peadiatric Center of Athens, Athens, Greece
4 Department of Anesthesiology, Peadiatric Center of Athens, Athens, Greece
5 Paediatric Intensive Care Unit, Peadiatric Center of Athens, Athens, Greece
6 Paediatric Respiratory and Allergy Department, Peadiatric Center of Athens, Athens, Greece
      PP28
   Background: Recurrent Respiratory Papillomatosis (RRP) is a rare condition caused by human papillomavirus (HPV) infection, especially with types 6 and 11. It is characterized by the presence of multiple airway warts which are located mainly in the larynx; lung involvement may also occur. There are two distinct types of the disease, Juvenile (JORRP) and Adult-onset RRP (AORRP). The most common form is the JORRP and affects children younger than 12 years of age. It is generally more aggressive with a high recurrence rate and is usually acquired by the vertical transmission during vaginal delivery of infected mothers. For years, there was no definitive cure for RRP and surgery remained the main treatment option. However, the systematic administration of Bevacizumab, a recombinant humanized monoclonal immunoglobulin that binds to vascular endothelial growth factor-A (anti-VEGF-A) and prevents angiogenesis, has recently been suggested for severe cases.
Case Presentation: Herein we describe a 15-month-old boy who presented with recurrent and progressively worsening episodes of inspiratory stridor over a period of two months. The patient was treated by his primary care physician with repeated courses of oral dexamethasone but showed only partial and transient response. He underwent flexible bronchoscopy which revealed multiple papillomatous lesions in the trachea and the main bronchi - but not in the larynx - causing a significant obstruction interpreting patient’s progressively worsening respiratory distress. Endobronchial biopsies were obtained and the diagnosis of papillomatosis was confirmed through histopathological analysis.The polymerase chain reaction detected HPV type 16. Chest computed tomography showed bilateral atelectasis of lower lobes but no spread of the HPV infection to the lung parenchyma.Notably,the patient was born by caesarean section and furthermore, his mother had no evidence of HPV infection with a recent PAP test being negative.The patient was diagnosed with JORRP and started on systematic anti-VEGF-A therapy (Bevacizumab).A significant clinical improvement was observed after the first dose. Flexible bronchoscopy was repeated after the administration of the third dose and showed dramatic regression of the papillomas. During the last 4 months the patient has received 6 intravenous doses of Bevacizumab (10 mg/kg/ dose) and remains free of symptoms.
Conclusion: Treatment with Bevacizumab is a promising option for patients with aggressive JORRP that can reduce or even eliminate the need for surgery and improve dramatically the life quality of these patients.
ECBIP 2021 59
6th European Congress
for Bronchology and Interventional Pulmonology
OCTOBER ECBIP 15 - 17
ATHENS - GREECE 2021
Book of Abstracts
    









































































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